Dr. Annie Andrews, a pediatrician from Charleston, South Carolina, has officially announced her candidacy for the U.S. Senate seat in 2026. Andrews, a Democrat, aims to unseat four-term Republican incumbent Senator Lindsey Graham. Known for her spirited 2022 congressional run, Andrews brings both political experience and a fresh voice to the increasingly competitive South Carolina political landscape.
Criticism of Lindsey Graham’s Leadership and Political Shifts
Andrews’ decision to run is fueled by dissatisfaction with Senator Graham’s shifting political positions and what she calls a lack of steadfast principles. In a statement to The Associated Press, Andrews criticized Graham for flip-flopping on major issues, stating, “He has changed his position on almost every issue at that time… he does not stand for anything or believe in anything except his own re-election.”
Her campaign announcement video highlights Graham’s evolving stance on former President Donald Trump—from harsh critic to staunch ally—which Andrews describes as “embarrassing.” The video also targets Graham’s votes during Trump’s presidency, including cabinet confirmations, framing them as betrayals of the American people.
South Carolina’s Political Climate and Democratic Challenges
South Carolina has long been a Republican stronghold, with Democrats struggling to gain traction statewide. Graham secured his last victory in 2020 by a 10-point margin, and despite record-breaking fundraising by his opponents, Democrats have yet to win a Senate seat in recent decades. Andrews acknowledges the uphill battle but believes growing voter discontent, especially following chaotic national policies, may shift the political balance.
Focus on Children’s Issues and Community Advocacy
As a pediatrician and mother, Andrews places special emphasis on issues impacting children, such as climate change, gun violence, and childhood poverty. After her 2022 congressional bid, she left her medical post at the Medical University of South Carolina to found a political organization dedicated to children’s rights. Through this non-profit, Andrews has actively promoted education, healthcare, and environmental initiatives, while her political action committee contributed to progressive candidates in 2024.
Growing Field of Democratic Challengers
Andrews is currently the most prominent Democrat challenging Graham, but at least one other Democratic candidate has announced plans to run. Meanwhile, Graham has launched his campaign for a fifth Senate term, backed by top Republicans including Governor Henry McMaster and Senator Tim Scott.
High-Stakes Race Shaping Up in 2026
The 2026 Senate race in South Carolina is expected to be highly competitive and expensive, with national Democratic and Republican organizations investing heavily. Both candidates will seek to leverage their strengths: Graham emphasizing his long Senate tenure and role in securing federal resources, and Andrews campaigning on progressive issues and a vision for change.
Conclusion: A Pivotal Election for South Carolina’s Future
Dr. Annie Andrews’ entry into the 2026 Senate race signals a dynamic challenge to established Republican dominance in South Carolina. With a platform focused on healthcare expansion, climate action, and children’s welfare, Andrews aims to connect with younger voters and suburban communities seeking new leadership. As the campaign unfolds, South Carolinians will decide whether to continue with Graham’s long-standing tenure or embrace Andrews’ call for a fresh direction in Washington.